International Ki67 in Breast Cancer Working Group

Welcome to the International Ki67 in Breast Cancer Working Group

Who are we

In 2009, the International Ki67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group formed to address the problem of inter-laboratory inconsistency in Ki67 assessment. It proposed guidelines for preanalytical and analytical conditions for Ki67 assessment, as well as for interpretation, scoring, and related data handling.1

1. Dowsett M, Nielsen TO, A’Hern R et al. Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer Working Group. J Natl Cancer Inst 2011;103:1656–1664.

Our Mission

  • propose guidelines for preanalytical and analytical conditions for Ki67 assessment
  • develop and disseminate standardized scoring methods for visual/manual scoring
  • develop and disseminate standardized protocol for automated scoring
  • to provide a centralized repository / hub to keep the community appraised of current research related to Ki67 as well as clinical practices involving Ki67.

Core Group

Core Group Affiliation
Mitch Dowsett (Chair) Academic Department of Biochemistry, Royal Marsden Hospital / Institute of Cancer Research, UK
Daniel F. Hayes (Co-Chair) Breast Oncology Program, Department of Internal Medecine, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Lisa M. McShane (Statistician) National Cancer Institute, Bethesda, Maryland, USA
Kelley M. Kidwell (Statistician) Department of Biostatistics, School of Public Health, University of Michigan
Torsten Nielsen (Pathologist) Genetic Pathology Evaluation Centre, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
Samuel Leung (Project Management) Genetic Pathology Evaluation Centre, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada

Working Group

Working Group Affiliation
Balazs AcsKarolinska Institutet, Stockholm, Sweden
Indu ArunTata Medical Center, Kolkata, West Bengal, India
Renaldas AugulisVilnius University Hospital Santara Clinics, Vilnius University, Vilnius, Lithuania
Sunil S. BadveIndiana University Simon Cancer Center, Indianapolis, Indiana, USA
Yalai BaiYale University School of Medicine, New Haven, Connecticut, USA
Anita L. BaneJuravinski Hospital and Cancer Centre, McMaster University, Hamilton, Ontario, Canada
John M.S. BartlettOntario Institute for Cancer Research, Toronto, Ontario, Canada
Jane BayaniOntario Institute for Cancer Research, Toronto, Ontario, Canada
Gilbert BigrasUniversity of Alberta, Edmonton, Alberta, Canada
Signe BorgquistSkane University Hospital, Lund University, Lund, Sweden
Martin C. ChangSinai Health System, University of Toronto, Toronto, Ontario, Canada
Carsten DenkertCharité Campus Mitte, Berlin, Germany
Andrew DodsonThe Institute of Cancer Research, London, United Kingdom
Anna EhingerSkane University Hospital, Lund University, Lund, Sweden
Susan FinebergMontefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York, USA
Cornelia M. FockeDietrich-Bonhoeffer Medical Center, Neubrandenburg, Mecklenburg-Vorpommern, Germany
Chad GalderisiMolecularMD, Portland, Oregon, USA
Dongxia GaoUniversity of British Columbia, Vancouver, British Columbia, Canada
Abhi GholapOptra Technologies, NeoPro SEZ, BlueRidge, Hinjewadi, India
Allen M. GownPhenoPath Laboratories, Seattle, Washington, USA
Carolina GutierrezLester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA
Douglas J. HartmanUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA
Judith C. HughUniversity of Alberta, Edmonton, Alberta, Canada
Anagha JadhavOptra Technologies, NeoPro SEZ, BlueRidge, Hinjewadi, India
Elizabeth N. KornagaTom Baker Cancer Centre, Alberta Health Services, Calgary, Alberta, Canada
Zuzana KosThe Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
Anne-Vibeke LænkholmZealand University Hospital, Slagelse, Region Sjælland, Denmark
Arvydas LaurinaviciusVilnius University Hospital Santara Clinics, Vilnius University, Vilnius, Lithuania
Richard LevensonUniversity of California Davis Medical Center, Sacramento, California, USA
Keith MillerPoundbury Cancer Institute, Poundbury, Dorset, United Kingdom
Takuya MoriyaKawasaki Medical School, Kurashiki, Okayama Prefecture, Japan
Sharon Nofech-MozesUniversity of Toronto Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
C. Kent OsborneLester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA
Liron PantanowitzUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA
Frédérique M. Penault-LlorcaCentre Jean Perrin and Université d'Auvergne, Clermont-Ferrand, France
Tammy PiperEdinburgh Cancer Research Centre, Western General Hospital, Edinburgh, United Kingdom
Jason RuanUniversity of California Davis Medical Center, Sacramento, California, USA
Takashi SakataniNippon Medical School, Bunkyo-ku, Tokyo, Japan
Roberto SalgadoInstitut Jules Bordet, Brussels, Belgium
Melanie SpearsOntario Institute for Cancer Research, Toronto, Ontario, Canada
Malini SrinivasanUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA
Jane StarczynskiBirmingham Heart of England, National Health Service, Birmingham, United Kingdom
Tomoharu SugieKansai Medical University, Hirakata, Osaka, Japan
Austin ToddUniversity of California Davis Medical Center, Sacramento, California, USA
Bert van der VegtUniversity Medical Center Groningen, Groningen, The Netherlands
Giuseppe VialeUniversity of Milan, Milan, Italy
Shakeel VirkQueen's University, Kingston, Ontario, Canada
Yihong WangRhode Island Hospital, Brown University, Providence, Rhode Island, USA
Ying WuJuravinski Hospital and Cancer Centre, McMaster University, Hamilton, Ontario, Canada
Lila A. ZabagloThe Institute of Cancer Research, London, United Kingdom

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This website was made possible by a generous grant from the Breast Cancer Research Foundation.